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rihexyphenidyl, also known as benzhexol, ARTANE, and trihex, is an antiparkinsonian agent of the antimuscarinic class. It has been in clinical usage for decades.
When ARTANE (trihexyphenidyl) is used concomitantly with levodopa, the usual dose of each may need to be reduced. Careful adjustment is necessary, depending on side effects and degree of symptom control. An ARTANE(trihexyphenidyl)dosage of 3 to 6 mg daily, in divided doses, is usually adequate.

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ARTANE Active Ingredient: Trihexyphenidyl is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson’s disease. It is also used to treat and prevent the same muscular conditions when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin),perphenazine (Trilafon),  drug used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson’s disease is also used to treat and prevent the same muscular conditions when they are caused by certain drugs.
ARTANE (trihexyphenidyl) is indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones.
As initial for parkinsonism, 1 mg of ARTANE (trihexyphenidyl) in tablet or elixir form may be administered the first day. The dose may then be increased by 2 mg increments at intervals of three to five days, until a total of 6 to 10 mg is given daily. The total daily dose will depend upon what is found to be the optimal level. Many patients derive maximum benefit from this daily total of 6 to 10 mg, but some patients, chiefly those in the postencephalitic group, may require a total daily dose of 12 to 15 mg.

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