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Human farnesyl pyrophosphate synthase (hFPPS) controls the post-translational prenylation of small GTPase proteins that are essential for cell signaling, cell proliferation, and osteoclast-mediated bone resorption. Inhibition of hFPPS is a clinically validated mechanism for the treatment of lytic bone diseases, including osteoporosis and cancer related bone metastases. A new series of thienopyrimidine-based bisphosphonates (THP-BPs) were identified that inhibit hFPPS with low nanomolar potency. Crystallographic evidence revealed binding of THP-BPB inhibitors in the allylic subpocket of hFPPS. Simultaneous binding of inorganic pyrophosphate in the IPP subpocket leads to conformational closing of the active site cavity. The THP-BP analogues are significantly less hydrophilic yet exhibit higher affinity for the bone mineral hydroxyapatite than the current N-BP drug risedronic acid. The antiproliferation properties of a potent ThB-BP analogue was assessed in a multiple myeloma cell line and found to be equipotent to the best current N-BP drugs. Consequently, these compounds represent a new structural class of hFPPS inhibitors and a novel scaffold for the development of human therapeutics.

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TH-PBP, A-PHP A-PVP is a powerful synthetic stimulant drug which functions as a norepinephrine-dpamine reuptake inhibitor (NDRI), being roughly a quarter the potency of MDPV the effects are said to be comparable.
A-PVP, α-Pyrrolidinopentiophenone is an alkaloid in the pyrrolidine and ketone chemical classes, functioning as a norepinephrine-dopamine reuptake inhibitor (NDRI) and acting as a stimulant on the central nervous system and cardiovascular system.
A-PVP was developed in the 1960 and has been available on the research chemical market for several years now, and is used as a recreational drug.
TH-PBP is a synthetic stimulant drug that has been sold online as a designer drug. It is very similar with α-PVP.
The form of TH-PBP is powder, purity is over 98.9%, a little yellow powder.
This product is intended for forensic and research facilities and is NOT intended for human consumption.
TH-PBP / A-PHP / A-PVP is a powerful synthetic stimulant drug which functions as a norepinephrine-dpamine reuptake inhibitor (NDRI), being roughly a quarter the potency of MDPV the effects are said to be comparable.
A-PVP, α-Pyrrolidinopentiophenone is an alkaloid in the pyrrolidine and ketone chemical classes, functioning as a norepinephrine-dopamine reuptake inhibitor (NDRI) and acting as a stimulant on the central nervous system and cardiovascular system.
A-PVP was developed in the 1960 and has been available on the research chemical market for several years now, and is used as a recreational drug.
TH-PBP is a synthetic stimulant drug that has been sold online as a designer drug. It is very similar with α-PVP.
The form of TH-PBP is powder, purity is over 98.9%, a little yellow powder.
This product is intended for forensic and research facilities and is NOT intended for human consumption.
Top quality and purity. Order now without prescription with delivery guarantee. Customer satisfaction is our priority.

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