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MDMA was first used in the 1970s as an aid in psychotherapy (mental disorder treatment using “talk therapy”). The drug didn’t have the support of clinical trials (studies using humans) or approval from the U.S. Food and Drug Administration. In 1985, The U.S. Drug Enforcement Administration labeled MDMA as an illegal drug with no recognized medicinal use. Some researchers remain interested in its value in psychotherapy when given to patients under carefully controlled conditions. MDMA is currently in clinical trials as a possible treatment aid for post-traumatic stress disorder and anxiety in terminally ill patients, and for social anxiety in autistic adults.

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MOLLY, the powder or crystal form of MDMA, the chemical used in Ecstasy, has been a popular drug at music festivals this year.
Molly, short for molecule, is considered to be pure MDMA, unlike Ecstasy, which generally is laced with other ingredients, such as caffeine or methamphetamine. According to Pax Prentiss, co-founder and CEO of Passages rehabilitation centers in Southern California, molly users tend to be ages 16 to 24.
The Drug Enforcement Administration (DEA) considers MDMA to be a Schedule I controlled substance, which means it has a high potential for abuse, and no accepted use in medical treatment. The DEA notes that MDMA can cause confusion, anxiety, depression, paranoia, sleep problems, and drug craving. The drug also can cause muscle tension, tremors, involuntary teeth clenching, muscle cramps, nausea, faintness, chills, sweating, and blurred “High doses of MDMA can interfere with the ability to regulate body temperature, resulting in a sharp increase in body temperature (hyperthermia), leading to liver, kidney and cardiovascular failure. Severe dehydration can result from the combination of the drug’s effects and the crowded and hot conditions in which the drug is often taken,” the DEA reports.
GDS first reported on the variations in routes of administration of MDMA more than 10 years ago (when it was simply the Mixmag Drugs Survey). At the time, we wrote something about the rectal use of MDMA (E-by-bum) because it sounded a bit funny. A few years ago, GDS followed that up with a more serious piece about the phenomena of people using drugs rectally, the science behind it (pardon the pun) and how rectal use of drugs may convey certain benefits, though it requires a bit of planning, patience, practice and equipment. GDS2017 took a more in depth look at the different way people use MDMA pills and powders around the world and that what I want to talk about here. Route of use is very important when thinking about drug effects (both pleasure and risk) and is probably overlooked compared to dose and drug purity. While the route you choose will be influenced by the form of drug you have at hand (pills or powder), 50% of our sample reported having used both pills and powder in the last 12 months (40% just powder and 10% just pills). Overall 90% of users take their MDMA orally (they swallow), while most of the remainder snort it .

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