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Pyridostigmine is a medication used to treat myasthenia gravis. It is also used together with atropine to end the effects of neuromuscular blocking medication of the non-depolarizing type. It is typically given by mouth but can also be used by injection.

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MESTINON Active Ingredient: (Pyridostigmine)
Mestinon (Pyridostigmine) is used for treating myasthenia gravis
Mestinon (pyridostigmine bromide) is a drug commonly used for treating myasthenia gravis. The drug is currently under investigation for spinal muscular atrophy (SMA).
Mestinon is a cholinesterase inhibitor that reversibly inhibits the esterase enzyme that is responsible for breaking down acetylcholine, a neurotransmitter that transmits nerve signals to the muscles, resulting in increased levels as well as duration of the acetylcholine activity.
SMA is a genetic neurodegenerative disease that involves impairment of the neuromuscular transmission. So Mestinon, which facilitates the nerve signal transmission at the neuromuscular junction (NMJ) by inhibiting acetylcholine breakdown, could be a potential therapy for SMA.It is an analog of Prostigmin (neostigmine), but Mestinon is effective for a longer period of time and has fewer side effects on the digestive system.
The drug is available as a regular tablet (60 mg), an extended-release tablet (180 mg), and a syrup (60 mg per teaspoon). The dose to be taken depends on the patient’s response. Its overdose may cause severe muscle weakness.
A doctor’s advice is recommended if the patient has allergies, asthma, seizures, heart disease, intestinal or urinary obstruction, or is taking other medications.
Safety information for its use in pregnant or breastfeeding women is inadequate. The benefits and risks of the drug should be carefully considered before it is used among these women.
Side effects include drowsiness, nausea, and pain in the abdomen.
Unused medication should be disposed of following a pharmacist’s instructions.

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